Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction.

ABSTRACT: The prenatal origins of heart disease in offspring have been established. However, research in species with developmental milestones comparable to humans is lacking, preventing translation of this knowledge to clinical contexts. Using sheep and chickens, two species with similar cardiovascular developmental milestones to humans, we combined in vivo experiments with in vitro studies at organ, cellular, mitochondrial, and molecular levels. We tested mitochondria-targeted antioxidant intervention with MitoQ against cardiovascular dysfunction programmed by developmental hypoxia, a common complication in human pregnancy. Experiments in sheep determined in vivo fetal and adult cardiovascular function through surgical techniques not possible in humans, while those in chicken embryos isolated effe

SUBMITTER: Botting KJ 

PROVIDER: S-EPMC7438086 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature