Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.

ABSTRACT:

Background and purpose

Atrial fibrillation (AF) is a leading cause of cardioembolic stroke, but the relationship between AF and noncardioembolic stroke subtypes are unclear. Because AF may be unrecognized, and because AF has a substantial genetic basis, we assessed for predisposition to AF across ischemic stroke subtypes.

Methods

We examined associations between AF genetic risk and Trial of Org 10172 in Acute Stroke Treatment stroke subtypes in 2374 ambulatory individuals with ischemic stroke and 5175 without from the Wellcome Trust Case-Control Consortium 2 using logistic regression. We calculated AF genetic risk scores using single-nucleotide polymorphisms associated with AF in a previous independent analysis across a range of preselected significance thresholds.

Result

SUBMITTER: Lubitz SA 

PROVIDER: S-EPMC7438180 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature