Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.

ABSTRACT:

Background & aims

The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising in young adults, with potential implications for reproductive-aged women. Whether NAFLD during pregnancy confers more serious risks for maternal or perinatal health is unclear.

Methods

Using weighted discharge data from the US national inpatient sample, we evaluated temporal trends of NAFLD in pregnancies after 20 weeks gestation, and compared outcomes to pregnancies with other chronic liver diseases (CLDs) or no CLD. Study outcomes included preterm birth, postpartum hemorrhage, hypertensive complications (pre-eclampsia, eclampsia, and/or hemolysis, elevated liver enzymes, and low platelets syndrome), and maternal or fetal death. NAFLD prevalence was estimated by calendar year and tempora

SUBMITTER: Sarkar M 

PROVIDER: S-EPMC7438303 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature