Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.

ABSTRACT: Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing impacts the regulatory role of ATEs remains unknown. Here, we show that ATEs undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice. We find that exposure to a young systemic environment partially restores ATE distribution in aged parabionts and reduces adipose tissue inflammation. Approaches to restore ATE distribution using adoptive transfer of eosinophils from young mice into aged recipients proved sufficient to dampen age-related local and systemic low-grade inflammation. Importantly, restoration of a youthful system

SUBMITTER: Brigger D 

PROVIDER: S-EPMC7438316 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature