Surface Triggered Self-Assembly of Fmoc-Tripeptide as an Antibacterial Coating.

ABSTRACT: In western countries, one patient on twenty will develop a nosocomial infection during his hospitalization at health care facilities. Classical antibiotics being less and less effective, this phenomenon is expanding year after year. Prevention of bacteria colonization of implantable medical devices constitutes a major medical and financial issue. In this study, we developed an antibacterial coating based on self-assembled Fmoc-tripeptide. Fmoc-FFpY peptides (F: phenylalanine; Y: tyrosine; p: PO₄ ^2-) are dephosphorylated enzymatically into Fmoc-FFY by action of alkaline phosphatase functionalized silica nanoparticles (NPs@AP), previously deposited on a surface. Fmoc-FFY peptides then self-assemble through π-π stacking interactions, hydrogen bonds and hydrophobic intera

SUBMITTER: Criado-Gonzalez M 

PROVIDER: S-EPMC7438842 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature