The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis.

ABSTRACT:

Background and aims

There are uncertainties about the epidemic patterns of HDV infection and its contribution to the burden of liver disease. We estimated the global prevalence of HDV infection and explored its contribution to the development of cirrhosis and hepatocellular carcinoma (HCC) among HBsAg-positive people.

Methods

We searched Pubmed, EMBASE and Scopus for studies reporting on total or IgG anti-HDV among HBsAg-positive people. Anti-HDV prevalence was estimated using a binomial mixed model, weighting for study quality and population size. The population attributable fraction (PAF) of HDV to cirrhosis and HCC among HBsAg-positive people was estimated using random effects models.

Results

We included 282 studies, comprising 376 population samples from 95 countr

SUBMITTER: Stockdale AJ 

PROVIDER: S-EPMC7438974 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature