[Trans-ethnic analysis of susceptibility variants in IgA nephropathy].

ABSTRACT:

Objective

To compare the genetic architecture of susceptibility variants of IgA nephropathy (IgAN) in Chinese and Europeans.

Methods

We selected the independent genome-wide significant variants of IgAN in European population as candidate variants. Their associations, risk alleles, risk allele frequencies, odds ratios and population attributable risk scores were derived and calculated, then compared with those in the current Chinese population, including 1 194 IgAN patients and 902 controls. Using the significant variants, genetic risk scores were calculated and compared between the East Asians and the Europeans. The correlation between the genetic risk scores and clinical manifestations was also evaluated.

Results

There were 16 independent single nucleotide polymorphi

SUBMITTER: Kang YQ 

PROVIDER: S-EPMC7439017 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature