GRB2-associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer.

ABSTRACT: The development of prostate cancer is complicated and involves a number of tumor-associated gene expression level abnormalities. Gene chip technology is a high-throughput method that can detect gene expression levels in different tissues and cells on a large scale. In the present study, gene chip technology was used to screen differentially expressed genes in PC-3 human prostate cancer cells following GRB-associated binding protein 2 (GAB2) gene knockdown, and the corresponding biological information was analyzed to investigate the role of GAB2 in prostate cancer. The PC-3 human prostate cancer cell GAB2 gene was knocked out and gene chip hybridization and bioinformatics methods were used to analyze the classical pathway and predict upstream regulatory molecules, disease and

SUBMITTER: Qiao XR 

PROVIDER: S-EPMC7439102 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature