Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach.

ABSTRACT: Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate me

SUBMITTER: Cardinale EM 

PROVIDER: S-EPMC7439289 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature