Association between the rs9131 and rs3806792 polymorphisms of the CXCL2 gene and the risk of HBV-related hepatocellular carcinoma in a Guangxi population.

ABSTRACT:

Background

Genetic polymorphisms in the CXCL2 may participate in the progress of HBV-related HCC. However, no researches have evaluated the association between them.

Methods

To figure out the effects of CXCL2 gene polymorphisms on the risk of HBV-related HCC, two major variants of CXCL2 and their association with chronic hepatitis B (CHB), HBV-related liver cirrhosis (LC), and HCC were conducted in a Guangxi population. CXCL2 polymorphisms rs9131 and rs3806792 were examined in 147 healthy controls, 138 CHB patients, 137 HBV-related LC patients, and 150 HBV-related HCC patients, using the SNaPshot™ genotyping technique.

Results

No significant differences were found regarding the CXCL2 rs9131 and rs3806792 polymorphisms among the case groups (including CHB, LC, and HCC)

SUBMITTER: Lu Y 

PROVIDER: S-EPMC7439333 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature