Association of SOX11 Polymorphisms in distal 3'UTR with Susceptibility for Schizophrenia.

ABSTRACT:

Background

Diverse and circumstantial evidence suggests that schizophrenia is a neurodevelopmental disorder. Genes contributing to neurodevelopment may be potential candidates for schizophrenia. The human SOX11 gene is a member of the developmentally essential SOX (Sry-related HMG box) transcription factor gene family and mapped to chromosome 2p, a potential candidate region for schizophrenia.

Methods

Our previous genome-wide association study (GWAS) implicated an involvement of SOX11 with schizophrenia in a Chinese Han population. To further investigate the association between SOX11 polymorphisms and schizophrenia, we performed an independent replication case-control association study in a sample including 768 cases and 1348 controls.

Results

After Bonferroni correct

SUBMITTER: Sun CP 

PROVIDER: S-EPMC7439430 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature