IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression.

ABSTRACT: Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to irreversible defects in the immune system. In addition to increased interleukin-6 (IL-6), we found aged mice exhibit increased systemic IL-10 that requires forkhead box P3-negative (FoxP3^-), but not FoxP3⁺, CD4⁺T cells. Most IL-10-producing cells manifested a T follicular helper (Tfh) phenotype and required the Tfh cytokines IL-6 and IL-21 for their accrual, so we refer to them as Tfh10 cells. IL-21 was also required to maintain normal serum levels of IL-6 and IL-10. Notably, antigen-specific Tfh10 cells arose after immunization of aged mice, and neutralization of IL-10 receptor signaling significantly restored Tfh-dependent antibody res

SUBMITTER: Almanan M 

PROVIDER: S-EPMC7439492 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature