Pharmacological Silencing of MicroRNA-152 Prevents Pressure Overload-Induced Heart Failure.

ABSTRACT:

Background

MicroRNAs are small, noncoding RNAs that play a key role in gene expression. Accumulating evidence suggests that aberrant microRNA expression contributes to the heart failure (HF) phenotype; however, the underlying molecular mechanisms are not well understood. A better understanding of the mechanisms of action of microRNAs could potentially lead to targeted therapies that could halt the progression or even reverse HF.

Methods and results

We found that microRNA-152 (miR-152) expression was upregulated in the failing human heart and experimental animal models of HF. Transgenic mice with cardiomyocyte-specific miR-152 overexpression developed systolic dysfunction (mean difference, -38.74% [95% CI, -45.73% to -31.74%]; P<0.001) and dilated cardiomyopathy. At th

SUBMITTER: LaRocca TJ 

PROVIDER: S-EPMC7439562 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature