A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control.

ABSTRACT: Multiple daily insulin injections have been a common regimen worldwide for the management of diabetes mellitus but involved potential safety and compliance problems. In this context, a single integrated microneedle patch (IMP) with multiple release kinetics is demonstrated to provide better physiologic insulin coverage for postprandial glycemic excursion in a convenient and pain-free manner. The combination of rapid separating technique and multiple individual microneedle arrays provides the combined ability to efficiently deliver insulin into the skin within seconds and to independently control insulin release kinetics. In addition, the diabetic rats with a traditional breakfast-lunch-dinner lifestyle exhibit obvious intraday glucose fluctuations, while the hypoglycemic experiments indica

SUBMITTER: Chen BZ 

PROVIDER: S-EPMC7439566 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature