Genetic Basis and Prognostic Value of Exercise QT Dynamics.

ABSTRACT:

Background

Abnormal QT interval responses to heart rate (QT dynamics) is an independent risk predictor for cardiovascular disease in patients, but its genetic basis and prognostic value in a population-based cohort have not been investigated.

Methods

QT dynamics during exercise and recovery were derived in 56 643 individuals from UK Biobank without a history of cardiovascular events. Genome-wide association studies were conducted to identify genetic variants and bioinformatics analyses were performed to prioritize candidate genes. The prognostic value of QT dynamics was evaluated for cardiovascular events (death or hospitalization) and all-cause mortality.

Results

Heritability of QT dynamics during exercise and recovery were 10.7% and 5.4%, respectively. Genome-wide a

SUBMITTER: van Duijvenboden S 

PROVIDER: S-EPMC7439940 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature