Late Acetaminophen Therapy for Patent Ductus Arteriosus in the Preterm Neonate.

ABSTRACT:

Objective

In preterm infants, the standard pharmacologic treatment for a hemodynamically significant patent ductus arteriosus (hsPDA) is either ibuprofen or indomethacin. However, these medications may be less effective after 2 weeks of age. We investigated the use of acetaminophen in hsPDA closure beyond 2 weeks of age.

Methods

An observational study of 11 infants, <30 weeks' gestation at birth and postnatal age > 2 weeks, who received acetaminophen treatment for their hsPDA. Echocardiograms (ECHOs), B-type natriuretic peptide (BNP) levels, and the fraction of inspired oxygen (FiO₂) were obtained before and after treatment to analyze ductal characteristics. Renal and liver functions were monitored pretreatment and posttreatment to look for potential medication si

SUBMITTER: King R 

PROVIDER: S-EPMC7439953 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature