Association between polymorphisms in the XRCC1 gene and male infertility risk: A meta-analysis.

ABSTRACT:

Background

X-ray repair cross-complementing group 1 (XRCC1) single nucleotide polymorphisms (SNPs) might correlate with male infertility susceptibility. This association has been described; however, the findings remain inconsistent. Consequently, this meta-analysis was conducted to characterize the relationship between XRCC1 SNPs and male infertility susceptibility.

Methods/main results

Studies were systematically searched in databases to evaluate the association between SNPs of XRCC1 and infertility in males. The effect measures chosen were the 95% confidence intervals (95% CIs) and odds ratios (ORs). A total of 7 studies, including 6 case-controlled studies on XRCC1 Arg399Gln and 3 case-controlled studies on XRCC1 Arg194Trp, were included. Ultimately, the results of this a

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7440050 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature