A simultaneous optical and electrical in-vitro neuronal recording system to evaluate microelectrode performance.

ABSTRACT:

Objectives

In this paper, we aim to detail the setup of a high spatio-temporal resolution, electrical recording system utilising planar microelectrode arrays with simultaneous optical imaging suitable for evaluating microelectrode performance with a proposed 'performance factor' metric.

Methods

Techniques that would facilitate low noise electrical recordings were coupled with voltage sensitive dyes and neuronal activity was recorded both electrically via a customised amplification system and optically via a high speed CMOS camera. This technique was applied to characterise microelectrode recording performance of gold and poly(3,4-ethylenedioxythiophene)/polystyrene sulfonate (PEDOT/PSS) coated electrodes through traditional signal to noise (SNR) calculations as well as the p

SUBMITTER: Aqrawe Z 

PROVIDER: S-EPMC7440637 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature