The complex pattern of genetic associations of leprosy with HLA class I and class II alleles can be reduced to four amino acid positions.

ABSTRACT: Leprosy is a chronic disease caused by Mycobacterium leprae. Worldwide, more than 200,000 new patients are affected by leprosy annually, making it the second most common mycobacterial disease after tuberculosis. The MHC/HLA region has been consistently identified as carrying major leprosy susceptibility variants in different populations at times with inconsistent results. To establish the unambiguous molecular identity of classical HLA class I and class II leprosy susceptibility factors, we applied next-generation sequencing to genotype with high-resolution 11 HLA class I and class II genes in 1,155 individuals from a Vietnamese leprosy case-control sample. HLA alleles belonging to an extended haplotype from HLA-A to HLA-DPB1 were associated with risk to leprosy. This susceptibility signal

SUBMITTER: Dallmann-Sauer M 

PROVIDER: S-EPMC7440659 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature