Association of ERCC5 Genetic Polymorphisms With Cirrhosis and Liver Cancer.

ABSTRACT:

Introduction

To explore association of excision repair cross-complementing 5 (ERCC5) genetic polymorphisms with cirrhosis and liver cancer.

Methods

A total of 365 patients were enrolled, including control group (n = 133), cirrhosis group (n = 122), and liver cancer group (n = 110). The genotyping of ERCC5 rs2016073, rs751402, rs2094258, rs2296147, and rs2296148 was measured by using MassARRAY iPLEX technology.

Results

There were no significant differences in gender and drinking among the 3 groups (P > .05). There were significant differences among the 3 groups in both age-group ≤60 and >60 subgroup patients. Locus rs2016073 was significantly different among 3 groups, and genotype GG (n = 0) was not observed in liver cancer group. As for locus rs75

SUBMITTER: Yang G 

PROVIDER: S-EPMC7440721 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature