The Integrated Analyses of Driver Genes Identify Key Biomarkers in Thyroid Cancer.

ABSTRACT:

Aim

Thyroid cancer is the most common endocrine cancer, the incidence rate has continuously increased worldwide. However, there are still lack of effective molecular biomarkers for the diagnosis and treatment of the disease. The study was conducted to identify driver genes that may serve as potential biomarkers for the disease.

Methods

The computational tools oncodriveCLUST, oncodriveFM, icages and drgap were used to detect driver genes in thyroid cancer using somatic mutations from The Cancer Genome Atlas database. Integrated analyses were performed on the driver genes using multiomics data from the TCGA database.

Results

A set of 291 driver genes were identified in thyroid cancer. BRAF, NRAS, HRAS, OTUD4, EIF1AX were the top 5 frequently mutated genes in thyr

SUBMITTER: Xu Q 

PROVIDER: S-EPMC7440732 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature