Circulating exosomal circFoxp1 confers cisplatin resistance in epithelial ovarian cancer cells.

ABSTRACT:

Objective

Early detection and treatment are particularly important to epithelial ovarian cancer (EOC). Studies have shown that circular RNA (circRNA) dysregulation is associated with the proliferation and metastasis of ovarian cancer cells. This study focused on the role of serum exosomal circular forkhead box protein P1 (circFoxp1) on survival outcome and cisplatin (DDP) resistance in patients with EOC.

Methods

Quantitative polymerase chain reaction, 5-ethynyl-2'-deoxyuridine (EdU) staining, CCK-8, luciferase reporter assay, RNA immunoprecipitation, tumor xenograft in nude mice, and bioinformatic analysis were performed.

Results

Circulating exosomal circFoxp1 was significantly increased in patients with EOC, especially in DDP-resistant EOC patients. circFoxp1 express

SUBMITTER: Luo Y 

PROVIDER: S-EPMC7440976 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature