MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity.

ABSTRACT: Localized prostate cancer develops very slowly in most men, with the androgen receptor (AR) and MYC transcription factors amongst the most well-characterized drivers of prostate tumorigenesis. Canonically, MYC up-regulation in luminal prostate cancer cells functions to oppose the terminally differentiating effects of AR. However, the effects of MYC up-regulation are pleiotropic and inconsistent with a poorly proliferative phenotype. Here we show that increased MYC expression and activity are associated with the down-regulation of MEIS1, a HOX-family transcription factor. Using RNA-seq to profile a series of human prostate cancer specimens laser capture microdissected on the basis of MYC immunohistochemistry, MYC activity, and MEIS1 expression were inversely correlated. Knockdown of MYC exp

SUBMITTER: Whitlock NC 

PROVIDER: S-EPMC7441006 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature