Compassionate drug (mis)use during pandemics: lessons for COVID-19 from 2009.

ABSTRACT:

Background

New emerging infections have no known treatment. Assessing potential drugs for safety and efficacy enables clinicians to make evidence-based treatment decisions and contributes to overall outbreak control. However, it is difficult to launch clinical trials in the unpredictable environment of an outbreak. We conducted a bibliometric systematic review for the 2009 influenza pandemic to determine the speed and quality of evidence generation for treatments. This informs approaches to high-quality evidence generation in this and future pandemics.

Methods

We searched PubMed for all clinical data (including clinical trial, observational and case series) describing treatment for patients with influenza A(H1N1)pdm09 and ClinicalTrials.gov for research that aimed to enrol p

SUBMITTER: Rojek AM 

PROVIDER: S-EPMC7441224 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature