BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk: A cohort study.

ABSTRACT:

Background

An association between BRCA pathogenic variants and an increased endometrial cancer risk, specifically serous-like endometrial cancer, has been postulated but remains unproven, particularly for BRCA2 carriers. Mechanistic evidence is lacking, and any link may be related to tamoxifen exposure or testing bias. Hysterectomy during risk-reducing bilateral salpingo-oophorectomy is, therefore, of uncertain benefit. Data from a large, prospective cohort will be informative.

Methods

Data on UK BRCA pathogenic variant carriers were interrogated for endometrial cancer diagnoses. Standardised incidence ratios (SIRs) were calculated in four distinct cohorts using national endometrial cancer rates; either from 1/1/1980 or age 20, prospectively from date of personal pathogenic

SUBMITTER: Kitson SJ 

PROVIDER: S-EPMC7441309 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature