GJB4 and GJC3 variants in non-syndromic hearing impairment in Ghana.
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ABSTRACT: Impact statement
Although connexins are known to be the major genetic factors associated with HI, only a few studies have investigated GJB4 and GJC3 variants among hearing-impaired patients. This study is the first to report GJB4 and GJC3 variants from an African HI cohort. We have demonstrated that GJB4 and GJC3 genes may not contribute significantly to HI in Ghana, hence these genes should not be considered for routine clinical screening in Ghana. However, it is important to study a larger population to determine the association of GJB4 and GJC3 variants with HI.
SUBMITTER: Adadey SM
PROVIDER: S-EPMC7441344 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
<i>GJB4</i> and <i>GJC3</i> variants in non-syndromic hearing impairment in Ghana.
Adadey Samuel M SM Esoh Kevin K KK Quaye Osbourne O Amedofu Geoffrey K GK Awandare Gordon A GA Wonkam Ambroise A
Experimental biology and medicine (Maywood, N.J.) 20200611 15
<h4>Impact statement</h4>Although connexins are known to be the major genetic factors associated with HI, only a few studies have investigated <i>GJB4</i> and <i>GJC3</i> variants among hearing-impaired patients. This study is the first to report <i>GJB4</i> and <i>GJC3</i> variants from an African HI cohort. We have demonstrated that <i>GJB4</i> and <i>GJC3</i> genes may not contribute significantly to HI in Ghana, hence these genes should not be considered for routine clinical screening in Gha ...[more]
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