CLCA4 and MS4A12 as the significant gene biomarkers of primary colorectal cancer.

ABSTRACT:

Background

Primary colorectal cancer (PCRC) is a common digestive tract cancer in the elderly. However, the treatment effect of PCRC is still limited, and the long-term survival rate is low. Therefore, further exploring the pathogenesis of PCRC, and searching for specific molecular targets for diagnosis are the development trends of precise medical treatment, which have important clinical significance.

Methods

The public data were downloaded from Gene Expression Omnibus (GEO) database. Verification for repeatability of intra-group data was performed by Pearson's correlation test and principal component analysis. Differentially expressed genes (DEGs) between normal and PCRC were identified, and the protein-protein interaction (PPI) network was constructed. Significant module

SUBMITTER: Han J 

PROVIDER: S-EPMC7441370 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature