Relationship Between Macular Curvature and Common Causative Genes of Retinitis Pigmentosa in Japanese Patients.

ABSTRACT:

Purpose

To determine the relationship between the macular curvature and the causative genes of retinitis pigmentosa (RP).

Methods

We examined the medical records of the right eyes of 65 cases with RP (31 men and 34 women; average age, 47.6 years). There were 31 cases with the EYS variants, 11 cases with the USH2A variants, six cases with the RPGR variants, 13 cases with the RP1 variants, and four cases with the RP1L1 variants. The mean curvature of Bruch's membrane was calculated within 6 mm of the fovea as the mean macular curvature index (MMCI, 1/µm). We used multiple linear regression analysis to determine the independence of the causative genes contributing to the MMCIs after adjustments for age, sex, axial length, and width of the ellipsoid zone.

Results

The medi

SUBMITTER: Koyanagi Y 

PROVIDER: S-EPMC7441377 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature