Acute-on-Chronic Liver Failure in Pregnant Patients with Chronic Hepatitis B: A Retrospective Observational Case Series Study.

ABSTRACT:

Background and aims

Acute-on-chronic liver failure (ACLF) is common in patients with end-stage liver disease and chronic hepatitis B (CHB) or hepatitis B virus- (HBV-) related cirrhosis. To date, no uniform definition and management strategy are available for ACLF. Although a considerable number of studies on ACLF has been published, there are few reports on ACLF in pregnant women with CHB. This study retrospectively reviewed five patients who were diagnosed with ACLF during pregnancy in the past 10 years. We aimed at investigating their clinical characteristics, treatment, biochemical test results, and maternal and fetal outcomes.

Results

Asthenia, anorexia, and jaundice were the main initial clinical manifestations in these patients during the second or third trimester of

SUBMITTER: Wang S 

PROVIDER: S-EPMC7441429 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature