Assessment of radial glia in the frontal lobe of fetuses with Down syndrome.

ABSTRACT: Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated with deviations in cortical development evidenced by simplified gyral appearance and reduced cortical surface area. Radial glia are neuronal and glial progenitors that also create a scaffolding structure essential for migrating neurons to reach cortical targets and therefore play a critical role in cortical development. The aim of this study was to characterise radial glial expression pattern and morphology in the frontal lobe of the developing human fetal brain with DS and age-matched controls. Secondly, we investigated whether microstructural information from in vivo magnetic resonance imaging (MRI) could reflect histological findings from human brain tissue samples. Immunohistochemistry was performed on

SUBMITTER: Baburamani AA 

PROVIDER: S-EPMC7441567 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature