Circulating Factors in Trauma Plasma Activate Specific Human Immune Cell Subsets.

ABSTRACT:

Background

Trauma causes tissue injury that results in the release of damage associated molecular patterns (DAMPs) and other mediators at the site of injury and systemically. Such mediators disrupt immune system homeostasis and may activate multicellular immune responses with downstream complications such as the development of infections and sepsis. To characterize these alterations, we used time-of-flight mass cytometry to determine how trauma plasma affects normal peripheral blood mononuclear cell (PBMC) activation to gain insights into the kinetics and nature of trauma-induced circulating factors on human immune cell populations. A better understanding of the components that activate cells in trauma may aid in the discovery of therapeutic targets.

Methods

PBMCs from healt

SUBMITTER: Cahill LA 

PROVIDER: S-EPMC7441590 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature