Ultrafast amidation of esters using lithium amides under aerobic ambient temperature conditions in sustainable solvents.

ABSTRACT: Lithium amides constitute one of the most commonly used classes of reagents in synthetic chemistry. However, despite having many applications, their use is handicapped by the requirement of low temperatures, in order to control their reactivity, as well as the need for dry organic solvents and protective inert atmosphere protocols to prevent their fast decomposition. Advancing the development of air- and moisture-compatible polar organometallic chemistry, the chemoselective and ultrafast amidation of esters mediated by lithium amides is reported. Establishing a novel sustainable access to carboxamides, this has been accomplished via direct C-O bond cleavage of a range of esters using glycerol or 2-MeTHF as a solvent, in air. High yields and good selectivity are observed while operat

SUBMITTER: Fairley M 

PROVIDER: S-EPMC7441706 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature