Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso.

ABSTRACT:

Background

Investigating malaria transmission dynamics is essential to inform policy decision making. Whether multiplicity of infection (MOI) dynamic from individual infections could be a reliable malaria metric in high transmission settings with marked variation in seasons of malaria transmission has been poorly assessed. This study aimed at investigating factors driving Plasmodium falciparum MOI and genetic diversity in a hyperendemic area of Burkina Faso.

Methods

Blood samples collected from a pharmacovigilance trial were used for polymerase chain reaction genotyping of the merozoite surface proteins 1 and 2. MOI was defined as the number of distinct parasite genotypes co-existing within a particular infection. Monthly rainfall data were obtained from satellite data of th

SUBMITTER: Sondo P 

PROVIDER: S-EPMC7441709 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature