Antimicrobial drug use in the first decade of life influences saliva microbiota diversity and composition.

ABSTRACT:

Background

The human microbiota contributes to health and well-being. Antimicrobials (AM) have an immediate effect on microbial diversity and composition in the gut, but next to nothing is known about their long-term contribution to saliva microbiota. Our objectives were to investigate the long-term impact of AM use on saliva microbiota diversity and composition in preadolescents. We compared the lifetime effects by gender and AMs. We used data from 808 randomly selected children in the Finnish Health In Teens (Fin-HIT) cohort with register-based data on AM purchases from the Social Insurance Institution of Finland. Saliva microbiota was assessed with 16S rRNA (V3-V4) sequencing. The sequences were aligned to the SILVA ribosomal RNA database and classified and counted using the mot

SUBMITTER: Raju SC 

PROVIDER: S-EPMC7441731 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature