Exploring the classification of cancer cell lines from multiple omic views.

ABSTRACT:

Background

Cancer classification is of great importance to understanding its pathogenesis, making diagnosis and developing treatment. The accumulation of extensive omics data of abundant cancer cell line provide basis for large scale classification of cancer with low cost. However, the reliability of cell lines as in vitro models of cancer has been controversial.

Methods

In this study, we explore the classification on pan-cancer cell line with single and integrated multiple omics data from the Cancer Cell Line Encyclopedia (CCLE) database. The representative omics data of cancer, mRNA data, miRNA data, copy number variation data, DNA methylation data and reverse-phase protein array data were taken into the analysis. TumorMap web tool was used to illustrate the landscape of m

SUBMITTER: Yang X 

PROVIDER: S-EPMC7441922 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature