Inhibition of voltage-gated Na⁺ currents by eleclazine in rat atrial and ventricular myocytes.

ABSTRACT:

Background

Atrial-ventricular differences in voltage-gated Na⁺ currents might be exploited for atrial-selective antiarrhythmic drug action for the suppression of atrial fibrillation without risk of ventricular tachyarrhythmia. Eleclazine (GS-6615) is a putative antiarrhythmic drug with properties similar to the prototypical atrial-selective Na⁺ channel blocker ranolazine that has been shown to be safe and well tolerated in patients.

Objective

The present study investigated atrial-ventricular differences in the biophysical properties and inhibition by eleclazine of voltage-gated Na⁺ currents.

Methods

The fast and late components of whole-cell voltage-gated Na⁺ currents (respectively, I _Na and I _N

SUBMITTER: Caves RE 

PROVIDER: S-EPMC7442036 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature