Childhood perfluoroalkyl substance exposure and executive function in children at 8 years.

ABSTRACT:

Background

Toxicological studies highlight the potential neurotoxicity of perfluoroalkyl substances (PFAS) during fetal development. However, few epidemiological studies have examined the impact of childhood PFAS on neurodevelopment.

Methods

We employed data from 208 children in the Health Outcomes and Measures of the Environment Study, a birth cohort (Cincinnati, OH), to examine associations of six serum PFAS concentrations measured at 3 and 8 years with executive function assessed at 8 years using the validated parent-completed Behavior Rating Inventory of Executive Function survey. We used multiple informant models to identify susceptible windows of neurotoxicity to PFAS and executive function. We investigated trajectories of PFAS concentrations and whether sex modified t

SUBMITTER: Vuong AM 

PROVIDER: S-EPMC7442288 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature