Molecular correlates of cerebellar mutism syndrome in medulloblastoma.

ABSTRACT:

Background

Cerebellar mutism syndrome (CMS) is a common complication following resection of posterior fossa tumors, most commonly after surgery for medulloblastoma. Medulloblastoma subgroups have historically been treated as a single entity when assessing CMS risk; however, recent studies highlighting their clinical heterogeneity suggest the need for subgroup-specific analysis. Here, we examine a large international multicenter cohort of molecularly characterized medulloblastoma patients to assess predictors of CMS.

Methods

We assembled a cohort of 370 molecularly characterized medulloblastoma subjects with available neuroimaging from 5 sites globally, including Great Ormond Street Hospital, Christian Medical College and Hospital, the Hospital for Sick Children, King Hussein

SUBMITTER: Jabarkheel R 

PROVIDER: S-EPMC7442348 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature