Functional, Anatomical, and Morphological Networks Highlight the Role of Basal Ganglia-Thalamus-Cortex Circuits in Schizophrenia.

ABSTRACT: Evidence from electrophysiological, functional, and structural research suggests that abnormal brain connectivity plays an important role in the pathophysiology of schizophrenia. However, most previous studies have focused on single modalities only, each of which is associated with its own limitations. Multimodal combinations can more effectively utilize various information, but previous multimodal research mostly focuses on extracting local features, rather than carrying out research based on network perspective. This study included 135 patients with schizophrenia and 148 sex- and age-matched healthy controls. Functional magnetic resonance imaging, diffusion tensor imaging, and structural magnetic resonance imaging data were used to construct the functional, anatomical, and morphological

SUBMITTER: Zhao W 

PROVIDER: S-EPMC7442374 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature