ICOSLG-mediated regulatory T-cell expansion and IL-10 production promote progression of glioblastoma.

ABSTRACT:

Background

Targeting immune checkpoint proteins has recently gained substantial attention due to the dramatic success of this strategy in clinical trials for some cancers. Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of antitumor adaptive immunity. Although aberrant ICOSLG expression has been reported in glioma cells, the underlying mechanisms that promote glioblastoma (GBM) progression remain elusive.

Methods

Here, we investigated a causal role for ICOSLG in GBM progression by analyzing ICOSLG expression in both human glioma tissues and patient-derived GBM sphere cells (GSCs). We further examined its immune modulatory effects and

SUBMITTER: Iwata R 

PROVIDER: S-EPMC7442411 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature