State-Dependent Functional Dysconnectivity in Youth With Psychosis Spectrum Symptoms.

ABSTRACT: Psychosis spectrum disorders are conceptualized as neurodevelopmental disorders accompanied by disruption of large-scale functional brain networks. Dynamic functional dysconnectivity has been described in patients with schizophrenia and in help-seeking individuals at clinical high risk for psychosis. Less is known, about developmental aspects of dynamic functional network connectivity (dFNC) associated with psychotic symptoms (PS) in the general population. Here, we investigate resting state functional magnetic resonance imaging data using established dFNC methods in the Philadelphia Neurodevelopmental Cohort (ages 8-22 years), including 129 participants experiencing PS and 452 participants without PS (non-PS). Functional networks were identified using group spatial independent component a

SUBMITTER: Mennigen E 

PROVIDER: S-EPMC7442416 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature