Cardiorespiratory fitness predicts effective connectivity between the hippocampus and default mode network nodes in young adults.

ABSTRACT: Rodent and human studies examining the relationship between aerobic exercise, brain structure, and brain function indicate that the hippocampus (HC), a brain region critical for episodic memory, demonstrates striking plasticity in response to exercise. Beyond the hippocampal memory system, human studies also indicate that aerobic exercise and cardiorespiratory fitness (CRF) are associated with individual differences in large-scale brain networks responsible for broad cognitive domains. Examining network activity in large-scale resting-state brain networks may provide a link connecting the observed relationships between aerobic exercise, hippocampal plasticity, and cognitive enhancement within broad cognitive domains. Previously, CRF has been associated with increased functional connectivit

SUBMITTER: Kronman CA 

PROVIDER: S-EPMC7442492 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature