Age-related NAD⁺ decline.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) is an essential metabolite that is reported to decline in concentration in tissues of aged animals. Strategies to increase NAD⁺ availability have shown promise in treating many conditions in rodents, including age-related degeneration, which has in turn driven intense interest in the effects of supplements on human health. However, many aspects of NAD⁺ metabolism remain poorly understood, and human data are limited. Here, we discuss the state of the evidence for an age-related decline in NAD⁺, along with potential mechanistic explanations, including increased consumption or decreased synthesis of NAD⁺ and changes in the composition of cells or tissues with age. Key challenges for the field invol

SUBMITTER: McReynolds MR 

PROVIDER: S-EPMC7442590 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature