Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas.

ABSTRACT:

Purpose

Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide administration; however, they have been ineffective in providing significant increases in median survival. Antigen-specific cancer vaccines and immune checkpoint blockade may provide promising immunotherapeutic approaches for gliomas.

Experimental design

We have developed immunotherapy delivery vehicles based on synthetic high-density lipoprotein (sHDL) loaded with CpG, a Toll-like receptor-9 agonist, and tumor-specific neoantigens to target gliomas and elicit immune-mediated tumor regression.

Results

We demonstrate that vaccination with neoantigen peptide-sHDL/CpG cocktail in combination with anti-PD-L1 immune che

SUBMITTER: Scheetz L 

PROVIDER: S-EPMC7442596 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature