CD8⁺ T-cell-Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas.

ABSTRACT:

Purpose

Cancer immunoediting shapes tumor progression by the selection of tumor cell variants that can evade immune recognition. Given the immune evasion and intratumor heterogeneity characteristic of gliomas, we hypothesized that CD8⁺ T cells mediate immunoediting in these tumors.

Experimental design

We developed retrovirus-induced PDGF⁺ Pten ^-/- murine gliomas and evaluated glioma progression and tumor immunogenicity in the absence of CD8⁺ T cells by depleting this immune cell population. Furthermore, we characterized the genomic alterations present in gliomas that developed in the presence and absence of CD8⁺ T cells.

Results

Upon transplantation, gliomas that developed in the absence of CD8⁺

SUBMITTER: Kane JR 

PROVIDER: S-EPMC7442699 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature