Subclinical Retinal versus Brain Findings in Infants with Hypoxic Ischemic Encephalopathy.

ABSTRACT:

Purpose

To detect retinal features and abnormalities on optical coherence tomography (OCT) without pupil dilation and relate these to brain injury in infants with a clinical diagnosis of hypoxic ischemic encephalopathy (HIE).

Methods

Under an institutional review board-approved protocol, we imaged eight infants without pharmacologic mydriasis, using handheld, non-contact spectral-domain (Leica Microsystems, IL) or investigational swept-source OCT at the bedside in an intensive care nursery, after birth (depending on primary clinical care team permission based on health status) and weekly until discharge. The newborn infant with HIE is neurologically unstable; therefore, pharmacologic mydriasis and stimulation with visible light for retinal examination are usually avoided. We

SUBMITTER: Mangalesh S 

PROVIDER: S-EPMC7442701 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature