A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders.

ABSTRACT: HIV-associated neurocognitive disorders (HAND) describe a spectrum of neuropsychological impairment caused by HIV-1 infection. While the sequence of cellular and physiological events that lead to HAND remains obscure, it likely involves chronic neuroinflammation. Host genetic markers that increase the risk for HAND have been reported, but replication of such studies is lacking, possibly due to inconsistent application of a behavioral phenotype across studies. In the current study, we used histopathologic phenotypes in order to validate putative risk alleles for HAND. The National NeuroAIDS Tissue Consortium, a longitudinal study of the neurologic manifestations of HIV. Data and specimens were obtained from 175 HIV-infected adults. After determining several potential covariates of neurocogn

SUBMITTER: Levine AJ 

PROVIDER: S-EPMC7442707 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature