A universal trade-off between growth and lag in fluctuating environments.

ABSTRACT: The rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial resources, affecting, for example, the expression levels of proteins dedicated to metabolism and biosynthesis^1,2. It is unclear, however, what ultimately determines growth rates in different environmental conditions. Moreover, increasing evidence suggests that other objectives are also important^3-7, such as the rate of physiological adaptation to changing environments^8,9. A common challenge for cells is that these objectives cannot be independently optimized, and maximizing one often reduces another. Many such trade-offs have indeed been hypothesized on the basis of qualitative correlative studies^8-11. Here we report a trade-off between steady-state gr

SUBMITTER: Basan M 

PROVIDER: S-EPMC7442741 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature