Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesis†.

ABSTRACT: During spermiogenesis in mammals, actin filaments and a variety of actin-binding proteins are involved in the formation and function of highly specialized testis-specific structures. Actin-based motor proteins, such as myosin Va and VIIa, play a key role in this complex process of spermatid transformation into mature sperm. We have previously demonstrated that myosin VI (MYO6) is also expressed in mouse testes. It is present in actin-rich structures important for spermatid development, including one of the earliest events in spermiogenesis-acrosome formation. Here, we demonstrate using immunofluorescence, cytochemical, and ultrastructural approaches that MYO6 is involved in maintaining the structural integrity of these specialized actin-rich structures during acrosome biogenesis in mouse.

SUBMITTER: Zakrzewski P 

PROVIDER: S-EPMC7442776 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature