Human Pegivirus Infection and Lymphoma Risk: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Human pegivirus (HPgV) is a single-strand RNA virus belonging to the Flaviviridae. Although no definitive association between HPgV infection and disease has been identified, previous studies have suggested an association of HPgV viremia with risk of lymphomas.

Methods

We conducted a systematic review and meta-analysis, including 1 cohort study and 14 case-control studies, assessing the association of HPgV viremia with adult lymphomas. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model, overall and by geographic region and lymphoma subtype.

Results

The overall OR for lymphoma was 2.85 (95% CI, 1.98-4.11), with statistically significantly elevated ORs observed in 8 of 15 studies. There was a small amount of heter

SUBMITTER: Fama A 

PROVIDER: S-EPMC7442854 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature